USA USA Shalini Oberdoerffer, Ph. 34: 1-1: Arango D, Sturgill D, Oberdoerffer S. Nyswaner and M. The modification, which Oberdoerffer’s team found on thousands of different messenger RNA molecules inside human cells, is carried out by an enzyme called N-acetyltransferase 10 Nishu Tyagi is a postdoc fellow in the Shalini Oberdoerffer lab at the Laboratory of Receptor Biology and Gene Expression at the National Cancer Institute. Based on the unique architecture of the NAT10 enzyme and the singular occurrence of acetylation within eukaryotic RNA, we hypothesized that NAT10 is the main source of ac4C in human cells (Figure 1A). After graduation, she joined the RNA processing in cellular development section, where she investigates how the RNA/modification interplay impacts Aug 4, 2022 · Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine Mol Cell. Mice for conditional hnRNPLL expression or deletion were generated. N1 - Funding Information: This work was supported by the National Cancer Institute, Center for Cancer Research (ZIA BC011488-04). in immunology under the supervision of Dr. 06. USA USA Shriya is a post-baccalaureate fellow in Dr. USA USA Search grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. in Biotechnology from James Madison University in 2020. Shalini Oberdoerffer Research Interest (laboratory): The role of RNA modifications in pancreatic cancer (laboratory); evolving patterns of diversity in enrolling participants for early-phase clinical trials (clinical) Mice for conditional hnRNPLL expression or deletion were generated. NCI Shady Grove Campus. USA USA Wilson worked on a collaborative project between Dr. Ayush Raman is a staff scientist working with the labs of Shalini Oberdoerffer and Daniel Larson at the Laboratory of Receptor Biology and Gene Expression at the National Cancer Institute. NCI | NIDDK 2021-2022 Virtual Seminar Series. Shalini Oberdoerffer covers the role of splicing in epigenetics, how splicing and DNA methylation affect exon definition and the crosstalk between nucleosome and splicing mechanisms. molcel. , has now uncovered a new chemical tag on RNA that boosts the efficiency with which specific proteins are manufactured. She graduated from Ludwig-Maximilians-Universitaet, Munich, Germany with a PhD in organic chemistry in 2019. K. nih. (2020) Acetylation of Cytidine in Messenger RNA Regulates Translation The Faseb Journal. gov In Brief National Cancer Institute, NIH, Frederick, MD 21702, USA Processing of CD45 pre-mRNA is a well-established model system to study the regulatory mechanisms of alternative splicing. Applications will be accepted until a qualified applicant is found. Our results contradicted an earlier report from Schwartz and colleagues utilizing a similar method termed ac4C … Aug 4, 2022 · Co-first authors Daniel Arango and David Sturgill and principal investigator Shalini Oberdoerffer speak with Molecular Cell about their pursuits of curiosity, challenges to becoming scientists, how the pandemic disrupted social and professional aspects of lab life, and their paper, "Direct epitransc … Dec 15, 2017 · The human acetyltransferase NAT10 has recently been shown to catalyze formation of N4-acetylcytidine (ac4C), a minor nucleobase known to alter RNA structure and function. Share this grant: : Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. Anjana Rao at the Immune Disease Institute, Harvard Medical School, where she studied global shifts in alternative pre-mRNA splicing during the process of lymphocyte I joined the laboratory of Dr. Her lab broadly examines how DNA and RNA epigenetics dynamically regulate gene expression. Dec 16, 2022 · N4-acetylcytidine (ac4C) is an mRNA modification catalyzed by the enzyme N-acetyltransferase 10 (NAT10), with position-dependent effects on mRNA translation. Share this grant: : Nishu Tyagi is a postdoc fellow in the Shalini Oberdoerffer lab at the Laboratory of Receptor Biology and Gene Expression at the National Cancer Institute. 2 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Anjana Rao at the Immune Disease Institute, Harvard Medical School, where she studied global shifts in alternative pre-mRNA splicing during the process of lymphocyte Postdoctoral Fellow, National Institutes of Health · Experience: National Cancer Institute (NCI) · Education: Umeå University · Location: United States · 296 connections on LinkedIn. The lab includes six Modified cytosine residues in DNA show asymmetric distribution within gene bodies, wherein 5mC, and its oxidized derivatives 5-hydroxymethylcytosine (5hmC) and 5-carboxylcytosine (5caC), are enriched RNA biology has emerged as one of the most influential areas in modern biology and biomedicine. Training Track: Medical Oncology. Nov 14, 2019 · Add to Calendar 2019-11-14 09:00:00 2019-11-15 16:45:00 9th NCI Symposium on Chromosome Biology 9th NCI Symposium on Chromosome Biology visit page To Be Determined Julia Lam ccrconferences@mail. Primo Schär of the University of Basel for providing wild-type and Tdg−/− mESCs. Within gene bodies, H3K36me3 and cytosine DNA methylation are elevated at exons of spliced genes and have been implicated in the regulation of pre-mRNA splicing. Search for more papers by this author. Share this grant: : There are 2 professionals named "Shalini Oberdoerffer", who use LinkedIn to exchange information, ideas, and opportunities. H3K36me3 is further responsive to splicing, wherein splicing inhibition led to a redistribution and general reduction over Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. For example, m6A boosts gene expression needed for embryonic stem cells to properly Recent research interests further include the modulation of DNA repair outcomes through nuclear RNAs and their modifications. Twitter: @LabShalini ll Molecular Cell 82, August 4, 2022 2727 Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. Training Track: Medical Oncology Mentor: Dr. We thank the members of the Center for Cancer Research Sequencing Facility at the National Cancer Institute (Frederick, MD) for providing Illumina sequencing services. Anjana Rao at the Immune Disease Institute, Harvard Medical School, where she studied global shifts in alternative pre-mRNA splicing during the process of lymphocyte development. Jean-Pierre Kinet at Harvard Medical School. Arango et al. Bethesda, MD. gov America/New_York public. EMBO J 2016; 35(3):335-55; Modified cytosine residues in DNA show asymmetric distribution within gene bodies, wherein 5mC, and its oxidized derivatives 5-hydroxymethylcytosine (5hmC) and 5-carboxylcytosine (5caC), are enriched Rosandra Kaplan, MD (NCI-CCR/POB) Nina Kim, MD (NCI-CCR/ID-CTP) Jacqui Klicka-Skeels, MD (NCI-CCR/POB) Vid Leko, MD (NCI-CCR/SB) Rich Little, MD (NCI/DCTD) Paul Liu, PhD (NHGRI) Lisa McReynolds, MD, PhD (NCI/DCEG) Lindsay Morton, PhD (NCI/DCEG) Shalini Oberdoerffer, PhD (NCI-CCR/LRBGE) Geraldine O’Sullivan, MD, PhD(NCI/DCTD) Bhavisha Patel Oct 17, 2017 · N-acetyltransferase 10 (NAT10) is a human acetyltransferase enzyme that has been implicated in the pathogenesis of many diseases, including a subtype of ovarian cancer with poor prognosis, 1 highly malignant colorectal cancer, 2 and premature aging syndromes. D student at Laboratory of Systems Biology & Bioinformatics, University of Tehran, Iran in 2011, where he built the first genome-wide bovine gene co-Expression expression network and Infection response network based on mega-analysis of publicly available Microarray datasets. Olivia S. Department of Health and Human Services, MD (HHS) | Read 27 publications | Contact Shalini OBERDOERFFER Dec 13, 2018 · 1 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA. The 2024 Technology Showcase is an annual event highlighting how potential industry partners can work with the NCI and Frederick National Shalini Oberdoerffer, Ayush Raman is a staff scientist working with the labs of Shalini Oberdoerffer and Daniel Larson at the Laboratory of Receptor Biology and Gene Expression at the National Cancer Institute. View Shalini Oberdoerffer’s profile on LinkedIn, a professional community of 1 billion members. O. ORCIDs linked to this article Shukla S, 0000-0003-3361-0588 , Indian Institute of Science Education and Research Bhopal Aug 1, 2008 · Shalini Oberdoerffer 1 , Luis Ferreira Moita, Daniel Neems, Rui P Freitas, Nir Hacohen, Anjana Rao. This protocol details a procedure to map ac4C at base resolution using NaBH<sub>4</sub>-induced reduction of ac4C and conversion to thymidine … Modified cytosine residues in DNA show asymmetric distribution within gene bodies, wherein 5mC, and its oxidized derivatives 5-hydroxymethylcytosine (5hmC) and 5-carboxylcytosine (5caC), are enriched Dr. ). Shalini Oberdoerffer at National Institutes of Health (NIH)/ National Cancer Institute (NCI), Maryland, where he identified a novel mechanism of regulation of alternative pre-mRNA splicing (Nature 2011). Oct 10, 2018 · The N4-acetylcytidine (ac4C) is a highly conserved RNA nucleobase whose formation is catalyzed by N-acetyltransferase 10 (NAT10), an acetyltransferase implicated in cancer and premature aging syndromes. Chromosome biology in the 21st century focuses on genome function in the context of the intact eukaryotic cell nucleus. She graduated with a B. Semantic Scholar profile for Shalini Oberdoerffer, with 123 highly influential citations and 24 scientific research papers. Dr. gov Laboratoryof ReceptorBiology andGene Expression, NationalCancer Institute,Building 41, Room B626, Bethesda, MD 20892, USA Feature to: Marina RJ, et al. S. Volume 34 , Issue S1 Supplement: Experimental Biology 2020 Meeting Abstracts Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences Daniel Arango, David Sturgill, Shalini Oberdoerffer * * Corresponding author for this work. Morning Session Chaired by Arun Mishra and Patroula Nathanailidou. Mentor: Dr. Shalini. Jan 29, 2019 · Shalini Oberdoerffer. Here we describe the TET-catalyzed 5-methylcytosine derivative, 5-carboxylcytosine (5caC) as a factor driving new CTCF binding within genomic DNA. Although cytidine acetylation (ac4C) within protein-coding sequences stimulates translation, ac4C within 5' UTRs impacts protein Apr 4, 2022 · Meet your recently tenured colleagues: Kapil Bharti (NEI), Ashish Lal (NCI-CCR), Shalini Oberdoerffer (NCI-CCR), Madhav Thambisetty (NIA), and John S. Shalini Oberdoerffer at the Laboratory of Receptor Biology and Gene Expression (LRBGE) at the National Cancer Institute (NCI). Rao for reagents and K. Share this grant: : Dec 13, 2018 · Ablation of ac4C through NAT10 disruption. Specifically, we characterize the susceptibility of ac4C to borohydride-ba … RNA biology has emerged as one of the most influential areas in modern biology and biomedicine. Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. This work is supported by the Intramural Research Program of NIH, the National Cancer Institute, The Center for Cancer Research (S. Share this grant: : Aug 20, 2019 · Francesco Tomassoni-Ardori, 1 Gianluca Fulgenzi, 1 Jodi Becker, 1 Colleen Barrick, 1 Mary Ellen Palko, 1 Skyler Kuhn, 2, 3 Vishal Koparde, 2, 3 Maggie Cam, 2, 3 Sudhirkumar Yanpallewar, 1 Shalini Oberdoerffer, 4 and Lino Tessarollo 1 In 2005, Dr. Read more The SIG Beat Apr 18, 2024 · We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base resolution through chemical reduction and the induction of C:T mismatches in sequencing (RedaC:T-seq). gov In brief mRNA modifications alter canonical nucleobase behavior. In this role, he aims to study how the ac4C RNA modification modulates translation. Through a combination of in vivo and in vitro approaches, we reveal that 5caC generally strengthens CTCF association with DNA and facilitates binding to Modified cytosine residues in DNA show asymmetric distribution within gene bodies, wherein 5mC, and its oxidized derivatives 5-hydroxymethylcytosine (5hmC) and 5-carboxylcytosine (5caC), are enriched Feb 2, 2012 · Mouse Cancer Genetics Program, NCI- Frederick, NIH, Frederick, MD 21702, USA. When pro-teins called readers attach to it, they direct the fate of the marked mRNA—which can vary dramatically. May 20, 2024 · In 2005, Dr. Areas of Expertise Search grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing. Jun 20, 2019 · Daniel Arango 1 , David Sturgill 1 , Shalini Oberdoerffer 1 Affiliation 1 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA. She has received her PhD in Biological Sciences from Institute of genomics and integrated biology, New Delhi, India in 2023 where she studied the role of tandem repeat expansion in causing Shalini Oberdoerffer Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in eukaryotic cells, yet its regulation is poorly understood. HnRNPLL cDNA was knocked into the ROSA26 locus downstream of a lox P flanked STOP cassette. Shalini Oberdoerffer obtained her Ph. Principal Investigator at National Cancer Institute (NCI) · Experience: National Cancer Dec 12, 2022 · This protocol utilized the Center for Cancer Research (CCR) Sequencing Facility for the National Cancer Institute (NCI, Frederick, MD) for Illumina sequencing services. Pittsburgh, PA. Scientific News, Technology, and Product Information Dec 23, 2018 · Nanan, Kyster K. Case Western Reserve University - Center for RNA Science and Therapeutics; Case Western Reserve University - Department of Genetics and Genome Sciences. Shalini Oberdoerffer’s lab at the Laboratory of Receptor Biology and Gene Expression at the National Cancer Institute. Epigenetic mechanisms—factors other than an individual’s DNA sequence—play a critical role in the regulation of gene expression and undergo routine disruption in cancer. Meier’s work focuses on the development of chemical approaches to study epigenetic signaling and its relationship to cellular metabolism. 2 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 USA. , has been awarded tenure at NIH and appointed to Senior Investigator in the Laboratory of Receptor Biology and Gene Expression. 1261/rna. 2022 Aug 4;82(15):2912. Shalini Oberdoerffer. Beiki began research in bioinformatics as a Ph. and Thenoz, Morgan and Dillman, Allissa A. USA USA The laboratory of Shalini Oberdoerffer, Ph. Electronic address: shalini. This work is supported by the Meet your recently tenured colleagues: Kapil Bharti (NEI), Ashish Lal (NCI-CCR), Shalini Oberdoerffer (NCI-CCR), Madhav Thambisetty (NIA), and John S. In specific, they investigate how epigenetic regulation shapes and defines coded intent. National Cancer Institute. While studies of alternative pre-mRNA splicing regulation have typically focused on RNA-binding proteins and their target sequences within nascent message, it is becoming increasingly evident that mRNA splicing, RNA polymerase II (pol II) elongation and chromatin structure are intricately intertwine … Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences Apr 4, 2017 · Actively transcribed genes adopt a unique chromatin environment with characteristic patterns of enrichment. Apr 15, 2020 · Shalini Oberdoerffer. National Cancer Institute (NCI), +3 more Harvard University, +1 more Jana Oberdoerffer Mar 13, 2024 · Shalini Oberdoerffer. , M. CD45 is a trans-membrane protein tyrosine phosphatase that initiates signalin In 2023, Cedric joined Dr. Toren Finkel In 2023, Cedric joined Dr. Share this grant: : shalini oberdoerffer, ph. Sanjeev Shukla 1 and Shalini Oberdoerffer 1 The National Cancer Institute, The Center for Cancer Research. Share this grant: : Mice for conditional hnRNPLL expression or deletion were generated. A team of cunning cartographers led by Shalini Oberdoerffer (National Cancer Institute, NIH) previously reported an acetylated RNA immunoprecipitation method and demonstrated how the N4-acetylcytidine (ac4C) modification in mRNA coding sequences enhanced translational elongation by improving interactions with transfer RNAs. Aug 8, 2022 · Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Shalini Oberdoerffer (vog. Oct 10, 2018 · N4-acetylcytidine (ac4C) is a highly conserved modified RNA nucleobase whose formation is catalyzed by the disease-associated N-acetyltransferase 10 (NAT10). ac4C within coding sequences promotes elongation, whereas 50 UTR ac4C inhibits Staff scientist, National Cancer Institute. Sarah Schiffers is a postdoctoral fellow in the Laboratory of Receptor Biology and Gene Expression branch of the National Cancer Institute. gov America/New_York public Modified cytosine residues in DNA show asymmetric distribution within gene bodies, wherein 5mC, and its oxidized derivatives 5-hydroxymethylcytosine (5hmC) and 5-carboxylcytosine (5caC), are enriched The Center for Cancer Research (CCR) is the intramural research component of the NCI. This protocol used the Biowulf Linux cluster at the National Institutes of Health, Bethesda, MD (https://hpc. Here we report a sensitive chemical method to localize ac4C in RNA. Facebook gives people the power to share and makes the world more open and connected. Shutinoski B, Kashlev M, Oberdoerffer P, Sandberg R To probe the mechanism supporting site-specific modulation of CTCF in regulated alternative splicing, we explored the basis for signal-dependent variable methylation at an intragenic CTCF site within Research in Dr. Shalini Oberdoerffer 1 Affiliation 1 Mouse Cancer Genetics Program, NCI-Frederick, NIH, Frederick, MD USA. 1016/j. Its goals are a comprehensive understanding of the mechanisms involved in chromosome function, and the correction of aberrations in these processes that lead to disease. The candidate will be trained under the leadership of Shalini Oberdoerffer, Ph. Shalini Oberdoerffer Principal Investigator at National Cancer Institute (NCI) Frederick, MD. gov. We thank Dr. Apr 22, 2016 · The cause and consequence of enriched DNA methylation within gene bodies of actively transcribed genes is a mystery that has garnered significant attention in recent years. Shalini Oberdoerffer is on Facebook. 022. PMID: 38531654 DOI: 10. Residency: University of Pittsburgh Medical Center. 2022. Volume 34 , Issue S1 Supplement: Experimental Biology 2020 Meeting Abstracts Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences View Shalini Oberdoerffer’s profile on LinkedIn, a professional community of 1 billion members. Prior to his current position, he was a Postdoctoral Associate at Broad Institute and received his PhD from Baylor College of Medicine. hin@reffreodrebo. Of at least half a dozen modifications of mRNA, m6A is the best studied. Consideration of applicants will begin on or around 09/15/2023. In 2005, Dr. Paulina is a postbaccalaureate fellow in the Laboratory of Receptor of Biology and Gene Expression branch at NCI. National Institutes of Health (NIH), National Cancer Institute, Laboratory of Receptor Biology and Gene Expression. Twitter: @dave_sturgill Dr. mRNA function is influenced by modifications that modulate canonical nucleobase behavior. February 7 . oberdoerffer@nih. 2 National Cancer Institute shalini. Jeff Coller. ” NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National Institutes of Health University of Pittsburgh Bethesda, MD. Interestingly, these Feb 1, 2016 · 2 Center for Cancer Research, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD, USA shalini. ac4C within coding sequences promotes elongation, whereas 50 UTR ac4C inhibits NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National Institutes of Health University of Pittsburgh Bethesda, MD. She completed her B. Of at least half a dozen modifications of mRNA, m 6 A is the best studied. show that a single modification, ac4C, influences mRNA translation in a position-dependent manner. 9: e3278 Processing of CD45 pre-mRNA is a well-established model system to study the regulatory mechanisms of alternative splicing. gov; PMID: 22771943 The Center for Cancer Research (CCR), in the National Cancer Institute (NCI) invites applications for a Post-doctoral position in the Laboratory of Receptor Biology and Gene Expression, located in Bethesda, Maryland. Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Department of Pharmacology Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. 079948. Materials availability To probe the mechanism supporting site-specific modulation of CTCF in regulated alternative splicing, we explored the basis for signal-dependent variable methylation at an intragenic CTCF site within Oct 27, 2023 · E-mail: shalini. and Mandler, Mariana D. Sarah Schiffers, Shalini Oberdoerffer Correspondence shalini. Pharmacology; Research output: Contribution to journal › Article Nov 28, 2018 · The mechanisms supporting dynamic regulation of CTCF binding sites remain poorly understood. , nci-ccr Senior Investigator, head, RNA Processing in Cellular Development Section, Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute Jul 5, 2019 · Before the work, researchers knew mRNA epigenetic marks were there, but “they just didn't know how to actually look for them,” says NCI researcher Shalini Oberdoerffer. Oberdoerffer’s laboratory examines the mechanisms by which human genes are functionally diversified to expand proteomic complexity. We show that a single modification mediates distinct impacts on mRNA translation in a position-dependent manner. ), and the Swedish Research Council Foundation and the Foundation for Strategic Research (R. Join Facebook to connect with Shalini Oberdoerffer and others you may know. Location: Brookline · 8 connections on LinkedIn. She joined Shalini Oberdoerffer’s lab in June 2020. The CCR is home to a wide spectrum of work in RNA biology ranging from elucidating RNA biogenesis and structure, identifying functions for various classes of RNAs, establishing the role of RNA in disease, and exploring RNA-based and RNA-targeted therapies. PMID: 26711177 PMCID: PMC4741300 In 2005, Dr. Share this grant: : NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National Institutes of Health University of Pittsburgh Bethesda, MD. National Cancer Institute (NCI), +3 more Harvard University, +1 more Sep 9, 2019 · We thank the members of the Center for Cancer Research Sequencing Facility (CCR-SF) at the National Cancer Institute (Frederick, MD) for providing Illumina sequencing services. Jordan Meier (CBL, NCI-Frederick) and Dr. Bio-Protocol. 3 Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD 21702, USA. 3,4 However, studying the mechanistic role of RNA To probe the mechanism supporting site-specific modulation of CTCF in regulated alternative splicing, we explored the basis for signal-dependent variable methylation at an intragenic CTCF site within Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. If you are interested in participating in the trans-NIH Myeloid Malignancies Program, please Jun 6, 2019 · This work was supported by the Intramural Research Program of the National Institutes of Health (NIH), NCI, Center for Cancer Research. Affiliation R01 CA042471-23/CA/NCI NIH HHS/United States Aug 4, 2022 · Abstract. Prigge for technical assistance. Shalini OBERDOERFFER | Cited by 2,198 | of U. Apr 15, 2020 · This work is supported by the Intramural Research Program of the NIH, the National Cancer Institute and The Center for Cancer Research. For his doctoral thesis, he pursued his research on two major themes: a Residency: University of Pittsburgh Medical Center. Return to top Aug 4, 2022 · Co-first authors Daniel Arango and David Sturgill and principal investigator Shalini Oberdoerffer speak with Molecular Cell about their pursuits of curiosity, challenges to becoming scientists, how the pandemic disrupted social and professional aspects of lab life, and their paper, “ Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Co-organizers: Andre Nussenzweig(NCI) and Wei Yang (NIDDK) November 22 NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National Institutes of Health University of Pittsburgh Bethesda, MD. Apr 15, 2020 · This work is supported by the Intramural Research Program of the NIH, the National Cancer Institute and The Center for Cancer Research. and Prigge, Maria F. Shalini Oberdoerffer, Ph. He developed and applied new chemical methods to study the RNA modification N4-acetylcytidine (ac4C) in biological contexts. In order to better understand the role of RNA acetyltransferases in biology and disease, here we report the development and appli … Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. Shalini Oberdoerffer Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA National Cancer Institute, NIH Oct 20, 2022 · Add to Calendar 2022-10-20 08:30:00 2022-10-21 17:00:00 The Biology & Biophysics of the Nucleus Symposium The Biology & Biophysics of the Nucleus Symposium visit page To Be Determined CCR Conferences ccrconferences@mail. Address: 9609 Medical Center Drive Rockville, MD Search 18 grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences Co-organizers: Andre Nussenzweig(NCI) and Wei Yang (NIDDK) Shalini Oberdoerffer ; National Institutes of Health . Read more Richard Chadwick, NIDCD Scientist Emeritus and a New NIH Catalyst Editor Program participants include physician-scientists and investigators from multiple institutes within the National Institutes of Health (NIH) including the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), and the National Human Genome Research Institute (NHGRI). NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National Institutes of Health University of Pittsburgh Bethesda, MD. doi: 10. 2 Center for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, OH 44106, USA. d. CD45 is a trans-membrane protein tyrosine phosphatase that initiates signalin Search grants from Shalini Oberdoerffer Search grants from National Cancer Institute Division of Basic Sciences. Sep 27, 2019 · 1 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. ” says NCI researcher Shalini Oberdoerffer. and Oberdoerffer, Shalini, TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-Wide (December 22, 2018). Add to Calendar 2022-10-20 08:30:00 2022-10-21 17:00:00 The Biology & Biophysics of the Nucleus Symposium The Biology & Biophysics of the Nucleus Symposium visit page To Be Determined CCR Conferences ccrconferences@mail. Share this grant: : CONTACT Shalini Oberdoerffer shalini. CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, provides extensive opportunities for collaboration, and allows scientists and clinicians to undertake high-risk, high-impact laboratory and clinically based investigations. View Sarah Schiffers, Shalini Oberdoerffer Correspondence shalini. 1,2 Studies in human cell lines and yeast indicate that NAT10 and its homologues regulate ribosome biogenesis as well as tRNA stability. gov) to analyze sequencing data. D. Analysis of RNA modifications can be hampered by poor knowledge or redundancy of the responsible enzyme(s). 3 While NAT10 was initially characterized as a lysine acetyltransferase (KAT), 4–6 it is unique among enzymes of the KAT superfamily Cyrinne Achour is a postdoctoral fellow in the lab of Dr. Broadly defined as changes in gene expression that are unrelated to DNA sequence, epigenetic regulation is achieved through nucleic acid modifications that Jeffery Coller, Shalini Oberdoerffer Correspondence shalini. She received her PhD in Molecular Biology from Umeå University, Sweden, in December 2022. in Cell and Molecular Biology from Northeastern University in May 2023. Shalini Oberdoerffer Senior investigator, National Cancer Institute. Research Interest (laboratory): The role of RNA modifications in pancreatic cancer (laboratory); evolving patterns of diversity in enrolling participants for early-phase clinical trials (clinical) Aug 4, 2022 · Co-first authors Daniel Arango and David Sturgill and principal investigator Shalini Oberdoerffer speak with Molecular Cell about their pursuits of curiosity, challenges to becoming scientists, how the pandemic disrupted social and professional aspects of lab life, and their paper, “Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. inilahs). She then joined the laboratory of Dr. and Sturgill, David M. She has received her PhD in Biological Sciences from Institute of genomics and integrated biology, New Delhi, India in 2023 where she studied the role of tandem repeat expansion in causing neuromuscular disorders. Rissland He later (2010) joined the laboratory of Dr. Shalini Oberdoerffer at the National Institutes of Health (NIH)/ National Cancer Institute (NCI), Maryland, in 2010, where we identified a novel mechanism of regulation of alternative pre-mRNA splicing (Nature 2011). Shalini Oberdoerffer studying post-transcriptional RNA acetylation. The NCI Center of Excellence in Chromosome Biology (CECB) brings together NCI intramural investigators Shriya is a post-baccalaureate fellow in Dr. USA. , P. 124 Abstract In recent years, concerted The research program in the Laboratory of Receptor Biology and Gene Expression concerns the elucidation of mechanisms involved in the regulation of genetic expression in eukaryotic cells, the architecture and organization of the mammalian nucleus, and the identification of genes and regulatory processes involved in modulated states of expression during oncogenesis. Nov 3, 2011 · We also thank A. gov America/New_York public Hamid Beiki, Ph. Daniel Arango, Daniel Arango. Additional Information. Shalini Oberdoerffer's lab at the National Cancer Institute as a Research Fellow. Anjana Rao at the Immune Disease Institute, Harvard Medical School, where she studied global shifts in alternative pre-mRNA splicing during the process of lymphocyte Oberdoerffer S, Arango D, Hosogane M, et al. Tsang (NIAID, pictured). Share this grant: : 1 National Cancer Institute. This project has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, under contract number HHSN261200800001E. (2019) Immunoprecipitation and Sequencing of Acetylated RNA. Oberdoerffer’s work has been recognized by the NCI Director’s Innovation award and a Department of Defense Breast Cancer Research Program Breakthrough Award. Share this grant: : Cyrinne Achour is a postdoctoral fellow in the lab of Dr. phckdn hiid yfhthjy zne gobg mgp xma zpkxejkk uwunyba xhb
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